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Sunday, July 19, 2020 | History

2 edition of Targeting of antibacterial vesicles to oral surfaces. found in the catalog.

Targeting of antibacterial vesicles to oral surfaces.

Anne Marie Robinson

Targeting of antibacterial vesicles to oral surfaces.

by Anne Marie Robinson

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  • 3 Currently reading

Published by University of Manchester in Manchester .
Written in English


Edition Notes

Thesis (Ph.D.), University of Manchester, School of Biological Sciences.

ContributionsUniversity of Manchester. School of Biological Sciences.
The Physical Object
Pagination291p.
Number of Pages291
ID Numbers
Open LibraryOL17074627M

Increasing resistance of bacteria to antibiotics is a serious worldwide problem, and to combat resistant bacteria, new antibacterial approaches are to be developed. One alternative to traditional antibiotic therapy is photodynamic antimicrobial chemotherapy (PACT). PACT is based on excitation of photosensitizers (PS) capable of transferring the absorbed light energy to dissolved molecular 2 days ago  CiteScore: ℹ CiteScore: CiteScore measures the average citations received per peer-reviewed document published in this title. CiteScore values are based on citation counts in a range of four years (e.g. ) to peer-reviewed documents (articles, reviews, conference papers, data papers and book chapters) published in the same four calendar years, divided by the number of

  The antibacterial activity of the reactive liposomes encapsulating GO alone and in combination with HRP was assessed as a function of the time of exposure of biofilm to the liposomes and the time in the presence of the enzyme substrates glucose and iodide ions (Fig. 4 Fig. 5 Fig. 6) and glucose in the presence of saliva ().Fig. 3 shows the antibacterial activity of liposomes encapsulating The identified electrochemical activity of C. matruchotii shows that this can be a simple and effective test for evaluating the impact of antibacterial compounds, and such a method might be applicable to the polymicrobial oral biofilm on electrode surfaces, given four other oral pathogens have already been shown the current production ://

  ABSTRACT BOOK EUROBIOFILMS - 1 - Amsterdam, The Netherlands Abstract book targeting a number of periodontal Amsterdam, The Netherlands Session 1: Oral biofilms in health and disease S Biofilm Formation of Oral Bacteria by Membrane Vesicles from S. mutans Hidenobu Senpuku*, Ryo Nagasawa1, Itaru Suzuki1,   Useful applications would be in the selective targeting of cytotoxic compounds entrapped in vesicles to circulating tumor cells (Wolff , Biochim Biophys. Acta, , p. ), or applications of these immunoglobulin-associated vesicles in the development of diagnostic


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Targeting of antibacterial vesicles to oral surfaces by Anne Marie Robinson Download PDF EPUB FB2

Vesicles with a mean diameter of approximately nm penetrated readily into P. aeruginosa biofilm and infected mucus, whereas vesicles larger than 1 µm failed to do so.

Biofilm penetration and targeted, sustained release of amikacin, mediated by sputum or rhamnolipides in biofilm supernatants, resulted in superior in vivo efficacy of inhaled   Potential Role of Oral Rinses Targeting the Viral Lipid Envelope in SARS-CoV-2 Infection Model membrane vesicles (membrane fluidity, permeability, interdigitation, thickness, etc.) oral antimicrobial activity for up to 12 h.

67 It is a more effective antimicrobial in vivo because it binds to clean oral surfaces and is released over time Robinson A, Creeth J, Jones M () The specificity and affinity of immunoliposome targeting to oral bacteria. Biochim Biophys Acta – PubMed CrossRef Google Scholar Robinson A, Creeth J, Jones M () The use of immunoliposomes for specific delivery of antimicrobial agents to oral bacteria immobilized on :// The vesicles were Targeting of antibacterial vesicles to oral surfaces.

book using soy lecithin and water to produce liposomes, or increasing amounts of glycerol or propylene glycol (PG) in water (, 25, 50% v/v) to Biofilm targeting represents a great challenge for effective antimicrobial therapy. Increased biofilm resistance, even with the elevated concentrations of very potent antimicrobial agents, often leads to failed therapeutic outcome.

Application of biocompatible nanomicrobials, particularly liposomally-associated nanomicrobials, presents a promising approach for improved drug delivery to This chapter presents the available methods for the preparation of these materials, their application, type of bioactive glasses, factors that play a vital role in enhancing their antibacterial properties against various bacterial traits and a brief detail of techniques applied to carry out antibacterial studies of nanosized bioactive ://   Mucosal Immunology, now in its fourth edition, is the only comprehensive reference covering the basic science and clinical manifestations of mucosal infectious agents enter the body through the various mucous membranes, and many common infections take place in or on mucous membranes, making this subject an area of singular importance in the field of ://   Shao, P., Comolli, L.

& Bernier-Latmani, R. Membrane vesicles as a novel strategy for shedding encrusted cell surfaces. Minerals 4, 74–88 ().

CAS Google Scholar   A novel strategy was developed to prepare nanospheres and vesicles as drug carriers. The drug-loaded pectin nanospheres and vesicles were fabricated in aqueous media containing Ca2+ and CO32− ions under very mild conditions, which did not involve any surfactant.

Through adjusting the preparation conditions, nanosized drug delivery systems with diverse morphologies, that is,   ‘ Matrix enclosed bacterial populations adherent to each other and to surfaces or interfaces’ Costerton et al, • Biofilms are ubiquitous and form on virtually all surfaces immersed in natural aqueous environment • Biofilms are the preferred method of growth for most bacteria.

The aim of the work was to extract, characterize, and formulate Thymus capitatus (Tymbra capitata) essential oil in phospholipid vesicles: liposomes, glycerosomes and Penetration Enhancer-containing Vesicles (PEVs). The steam-distilled essential oil was mainly composed of carvacrol. The oil was mixed with lecithin and water to produce liposomes, or different ratios of water/glycerol or water   Oral administration of liposomes Topical applications of liposomes Liposomes for drug delivery to the lung Liposome pharmacokinetics in the lung Lung targeting Site specific drug delivery Liposome targeting Ligand-bearing liposomes Glycolipid and glycoprotein ligand-bearing liposomes   Search & Browse Publications That Feature Izon's Products.

Ap METASTASIS AND ADAPTIVE RESISTANCE INHIBITING IMMUNOTHERAPY COMBINED ONLINECHEMOTHERAPY (43): Dec, WITH RADIOTHERAPY’STUMOR SEEKING EXTRACELLULAR VESICLESWITH SIRNA AND CHEMOTHERAPEUTICS The phenomenon of adhesion is of cardinal importance in the pharmaceutical, biomedical and dental fields.

A few eclectic examples will suffice to underscore the importance/relevance of adhesion in these three areas. For example, the adhesion between powdered solids is of crucial importance in tablet manufacture.

The interaction between biodevices (e.g., stents, bio-implants) and body +in. The mouth supports the growth of diverse communities of microorganisms – viruses, mycoplasmas, bacteria, Archaea, fungi and protozoa (Wade ).These communities persist on all surfaces as multispecies biofilms and form the resident oral microbiome, which generally exists in harmony with the host, and delivers important benefits that contribute to overall health and well‐:// It has been found that vesicles incorporating phosphatidylinositol (PI) are effective at targeting to some oral and skin-associated bacteria possibly as a consequence of hydrogen bonding Antibacterial activity of wine samples was evaluated against Streptococcus mutans, responsible for dental caries, Streptococcus salivarius, and Streptococcus pyogenes, two oral bacterial ://   The ascending anxiety regarding antimicrobial resistance as well as the recalcitrant nature of biofilm-associated infections call for the development of alternative strategies to treat bacterial diseases.

Nanoparticles have been considered as one of the emerging and promising platforms in this respect. Their unique physical and chemical properties may lead to fine-tuned interactions between   84 incidence of antibiotic-resistant oral bacteria such as P.

gingivalis has increased [24–27], highlighting the need for new antibacterials targeting oral infections. 85 Recently, drug repurposing has emerged as a new86 strategy for the identification of new 87 antibacterial agents [28]. As the safety and pharmacokinetic profiles of market Antibacterial agents act against bacterial infection either by killing the bacterium or by arresting its growth.

They do this by targeting bacterial DNA and its associated processes, attacking bacterial metabolic processes including protein synthesis, or interfering with bacterial cell wall synthesis and  › Home › eBooks. Colloids and Surfaces B: Biointerfaces is an international journal devoted to fundamental and applied research on colloid and interfacial phenomena in relation to systems of biological origin, having particular relevance to the medical, pharmaceutical, biotechnological, food and cosmetic fields.

Submissions that: (1) deal solely with biological phenomena and do not describe the physico Antibacterial Agent. Antibacterial agents used in fiber include quaternary ammonium compounds, triclosan, metallic salts like silver, copper, zinc, and cobalt, and inorganic nanosized metal oxides, like titanium dioxide (TiO2), zinc oxide (ZnO), and cooper II oxide (CuO).

Targeting the virus-specific enzymes is an attractive option, and may   The use of natural and artificial extracellular vesicles (EVs) in drug delivery may help to solve the aforementioned problems faced by different DDSs.

Due to their self-origin, small size, flexibility, the presence of multiple adhesive molecules on their surfaces as well as their function as biomolecules carriers, EVs are the perfect candidates